Effect of surfactants or a water soluble polymer on the crystal
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Effect of surfactants or a water soluble polymer on the crystal transition of clarithromycin during a wet granulation process.
To generate products containing a stable form of clarithromycin (CAM) (form II) regardless of the initial crystal form of CAM or type of granulation solvent, the effects of five surfactants, or a water-soluble polymer (macrogol 400) were determined on the crystal transition of CAM. The metastable form (form I) was kneaded with water, after adding surfactants, or a water-soluble polymer. Form II...
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تاریخ انتشار 2015